सीएसबी - केंद्रीय रेशम उत्पादन अनुसंधान एवं प्रशिक्षण संस्थान , मैसूरु

Details of research Projects:

ResearchProject(s) Ongoing projects

1. Working as principal investigator in “Development and evaluation of anti-inflamatory and anti-acne cream from biomolecules extracted from waste generated from sericulture activities (BPS01050SNC)” (CSB funded project) April-2025 to March- 2025
2. Working as principal investigator in “Development of Antidiabetic formulations from mulberry leaf extract/ powder (2024-CSB-INC-31)” Collaborative project December-2024 to December-2025
3. Co-Investigator in CSB funded project on “Evaluation of Nualgi foliar and soil health on mulberry parameters, leaf quality and its effects on silkworm (2024-CSB-INC-32)” One year project
4. Co-Investigator in CSB funded project on “PIE06011MIC” collaborative project with CSGRT, Hosur.

Completed Projects

1. Worked as principal investigator in Pilot project on “Development of hygrotolerant bivoltine breed/hybrids through molecular marker assisted selection” (2017-18) (CSB funded project) (August 2017-July 2018)
2. Worked as co-ordinator in Ministry of textiles funded project on “Skill seeding and upgradation of skills in sericulture sector” (2014-15)
3. Worked as co-investigator in CSB funded project on “Studies on tolerance of AmCPV in commerically exploited tasar ecoraces of Daba BV and TV under induced condition” (2012-upto June 2014)
4. Worked as co-investigator in CSB funded project on “Identification of pebrinised& cytoplasmic polyhedrosis virus-infected stock through enzyme marker system in Antheraea mylitta Drury” (December 2011-November,2013).
5. Principalinvestigatorin CSBfundedprojecton “Isolationand characterizationofchitosanfromsilkwormpupalshellanditscommercial application” (PIC 01008 SI).
6. Co-Investigator in CSB funded project on “Evaluation of new bivoltine silkworm double hybrid TT21 X TT56 at farmers level for authorization and commercial exploitation” (AIB 01009 MI)
7. Co-Investigator in CSB funded project on “Screening of drugs/Inhibitors to inhibit the PI3K-Akt pathway in Bombyx mori for controlling Nuclear Polyhedrosis Virus infection” (AIT 01019 SI)
8. Co-Investigator in CSB funded project on “Development of artificial intelligence empowered multisensory approach for gender classification and separation of silkworm cocoons” (MFM 01020 CN)
9. Worked as principal investigator in “ Immunomodulatory and adjuvant effects of Chitosan nanoparticles extracted from Bombyx mori (BPS01027CN)” collaborative project from May 2022-October- 2024.
10. Worked as principal investigator in “Value addition of cellulose and chitin extracted from sericulture waste for advanced packaging applications (BPS01028CN)” collaborative project from May 2022-October- 2024

Book chapter:

Vinayarani,G.,Madhusudhan,K.N. andPrakash,H.S.2019.Diseasesofturmericandtheir management Book: Diseases of Medicinal and Aromatic Plants and Their Management EditorsRakeshPandey, A.K.Misra,H.B.Singh, AlokKalra andDineshSinghTTPToday& Tomorrow’s Printers and Publishers 4436/7, Ansari Road, Daryaganj, New Delhi - 110 002 pp: 29-46.

International conference attended:

Madhusudhan, K.N.*, Moorthy, S.M., Hukkeri, S.M., Teotia, R.S., and Tiwary, P. presented research paper on “Synthesis and characterization of antimicrobial chitosan and silk fibroin nanofibers (CS-SF Nanofibers)” (Oral Presentation) in 25th International Sericulturalcongress (ISC) held on November 19-22, 2019 at Tsukuba, Japan.

NCBIGene deposits

MN892552 KU247947 JX006081 GU213293 GU213294 EU408340 EU408341 EU408342 MH488808 KY971454 KY971448 MG488274 KY971444 MG488273 MG456576 MG456575 MG456574 MG456573 MG456572 MG456571 MF040157 MF040156 KY996477 KU247947 KU247946 MH229468 MH179338 MH179073 MH173842 MH173841 MH173838 MH173837 MH173835 MH173832 MH173833 MH173829 MH173820 MH173819 MH173818 MH173817 MH173810 MH173809 MH169594 MH169582 MH169581 MH169559 MH169352 MH169351 MH169343 MH169339 MH169239 MH169230 MH158544 MH014986 MH005100 MH005099 MH005070 MH001479 MH001475 MH001398 MG971220 MG966453 MG966452

PDBstructuredeposits

HomologymodeledstructuresofmovementproteinsofTobaccoMosaicVirus(TMV)and Tomato Mosaic Virus (ToMV) were deposited in Protein Data Bank (PDB) with ids 2IP5 (www.ebi.ac.uk/2ip5) and 2IP8 (www.ebi.ac.uk/2ip8) (www.rcsb.org)

Ten best publications:

1. Madhusudhan, K.N.,Prakash, H.S. and Shetty, H.S. 2009. Changes in antioxidant enzymes, endogenous hydrogen peroxide, endogenous salicylic acid concentrationand oxidative stress in compatible and incompatible host-tobamovirus interaction. Journal of plant interactions. 4(3):157–166.
2. Madhusudhan, K.N., Deepak, S.A., Prakash, H.S., Ganesh, K.A., Jwa, N.S., Randeep, R. 2008. Acibenzolar-S-Methyl (ASM) induced resistance against tobamoviruses involves induction of RNA dependent RNA polymerase (RdRp) and AlternativeOxidase(AOX)genes.JournalofCropScienceandBiotechnology.11 (2):127-134.
3. Madhusudhan, K.N.,Sivakumar, D. and Prakash, H.S. 2010. Pectin methylesterase estimation in plant-tobamovirus interaction and comparative modelling, active site prediction and Docking between the proteins involved in the movement of tobamoviruses. Journal of Computational Intelligence in Bioinformatics. 3(2): 163- 174.
4. Madhusudhan, K.N.,Nalini, M.S., Prakash, H.S. and Shetty, H.S. 2005. Effect of inducers against Tobamovirus infection in tomato and bell pepper. International Journal of Botany. 1(1): 59-61.
5. Madhusudhan, K.N., Siva Kumar, D., Mohitkumar, Sinha, A.K., Kirankumar, K.P. Reddy, P.M.M., Sinha, M.K.andJaishankar, C. 2014. Homologymodeling and Active site prediction of RNA binding protein of Anthereamylitta Cytoplasmic polyhedrosis (AmCPV) infecting tropical tasar silkworm. Indian Journal of Biotechnology and Biochemistry.1(2): 91-96.
6. Madhusudhan, K.N., Aakash, K., Gupta,V.P., Naqvi, A.H., Singh, G.P. and Sinha, A.K.. 2016. Development of Slide agglutination method for detection of Nosemamylitta in tasar silkworm using polyclonal antibodyproduced against proteins of pebrine spores. International Journal of Phamaceutics and Drug Analysis. 4(5):212- 216.
7. Madhusudhan, K.N., Vinayarani, G., Moorthy, S.M., Satish, L., Thirupathaiah, Y., Maheshwari, C., Prakash, H.S., Teotia, R.S. and Sivaprasad, V. 2019. Isolation, purification and characterization of antibacterial bioactive compounds from Bougainvillea spectabilis Leaf. Journal of Pharmacognosy and Phytochemistry 8(3): 2668-2673.
8. Madhusudhan, K.N., Meghana, P.B., Vinaya Rani G., Moorthy, S.M., Mary- Josepha, A.V., Kishorekumar, C.M., Prakash, H.S. and Sivaprasad, V. 2017. Extraction and Characterization of Chitin and Chitosan from Aspergillus Niger, Synthesis of Silver- Chitosan Nanocomposites and Evaluation of Their Antimicrobial Potential. Journal of advances in Biotechnology. 6(3): 939-945.
9. Madhusudhan. K. N.*, Ranjini. M. S., Manthira Moorthy, S., Teotia, R.S. and Sivaprasad, V. 2020. Identification of hygrotolerant genes in mulberry silkworm (Bombyx mori L.)". Bioscience BiotechnologyResearch Communication
10. Vinayarani,G.,Madhusudhan,K.N.,Deepak,S.A.,Niranjana,S.R.andPrakash, H.S. 2011. Detection of mixed infection of tabomoviruses in tomato and bell pepper by using RT-PCR and Duplex RT-PCR. International journal of Plant Pathology.2(2): 89-95.
11. Pandey, J.P., Jena, K.B., Sinha, A.K., Smitha, Kumar, K.P.K., Madhusudhan, K.N. and Sahay, A.K. 2015. Intonation of biomolecular indices in tasar silkworm challenged with Nosema spores. Sericologia. 55(1): 55-60.
12. Singh, G.P., Kiran Kumar,K.P., Madhusudhan,K.N. and AlokSahay. 2015. Impactof botanical formulation on containment of virosis disease and cellular and humoral response in tasar silkworm AntheraeamylittaD. International Journal of Research in Zoology.5(1): 13-20.
13. Singh,G.P.,A.K.Sinha,D.K.Roy,A.Sahay,K.N.Madhusudhan,P.K.Kumarand B.C. Prasad, 2011. Cellular and biochemical changes of Antheraeamylitta D. on Immunization with attenuated Antheraeamylitta cytoplasmic polyhedrosis virus. International Journal of Zoological Research.7(3): 263-271.
14. Singh, G.P., A.K. Sinha, K.N. Madhusudhan, P.K. Kumar, B.C. Prasad, D.K. Roy and Sahay, 2011. Attenuation of Antheraeamylitta Cytoplasmic Polyhedrosis Virus (AmCPV)and its potential as an oral vaccine against virus diseases in tasar silkworm, Antheraeamylitta D. International Journal of Virology. 7: 33-38.
15. Lokesh. G.,Putkho Paul Pao, K.N. Madhusudhan, P.K. Kar, A.K. Srivastava, M.K. Sinha,R. ManoharReddy, P.M. MuniswamyReddyand B.C. Prasad (2012). Studyof Phenotypic Variability in Silk Gland Characters in Three Ecoraces of Tropical silkworm Antheraea mylitta Drury. Asian Journal of Animal and Veterinary Advances. 7(1); 80-84.